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Kiyoshi Higashi Selected Research

HSc025

12/2015Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.
6/2014A novel small compound accelerates dermal wound healing by modifying infiltration, proliferation and migration of distinct cellular components in mice.
2/2011A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice.
11/2009A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis.

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Kiyoshi Higashi Research Topics

Disease

6Fibrosis (Cirrhosis)
12/2015 - 10/2003
4Neoplasms (Cancer)
01/2020 - 07/2012
4Liver Cirrhosis (Hepatic Cirrhosis)
01/2019 - 04/2008
2Adenocarcinoma
01/2020 - 06/2016
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2020 - 06/2016
2Wounds and Injuries (Trauma)
06/2014 - 04/2013
2Pulmonary Fibrosis (Fibrosing Alveolitis)
02/2011 - 11/2009
1Pruritus (Itching)
01/2024
1Atopic Dermatitis (Atopic Eczema)
01/2024
1Eczema
01/2024
1Liver Diseases (Liver Disease)
01/2019
1Phototoxic Dermatitis (Phototoxicity)
01/2017
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
12/2015
1Colitis
12/2015
1Lung Neoplasms (Lung Cancer)
02/2015
1Brain Neoplasms (Brain Tumor)
09/2014
1Stomach Neoplasms (Stomach Cancer)
09/2014
1Skin Ulcer
06/2014
1Insulinoma
08/2011
1Pheochromocytoma
11/2010
1Systemic Scleroderma (Systemic Sclerosis)
11/2009
1Chronic Hepatitis C
10/2003

Drug/Important Bio-Agent (IBA)

4AntigensIBA
01/2020 - 09/2014
4CollagenIBA
12/2015 - 10/2003
4HSc025IBA
12/2015 - 11/2009
3Transforming Growth Factors (Transforming Growth Factor)IBA
12/2015 - 02/2011
3Carbon Tetrachloride (Tetrachloromethane)IBA
02/2011 - 10/2003
3Transforming Growth Factor beta (TGF-beta)IBA
11/2009 - 07/2005
2Biomarkers (Surrogate Marker)IBA
01/2020 - 06/2016
2Granulocyte Colony-Stimulating Factor (G-CSF)IBA
01/2019 - 03/2012
2Monoclonal AntibodiesIBA
06/2016 - 09/2014
2CytokinesIBA
12/2015 - 03/2012
2Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA
03/2012 - 07/2005
2alpha2 Subunit Collagen Type IIBA
07/2005 - 10/2003
1Interleukin-13IBA
01/2024
1Interleukin-4 (Interleukin 4)IBA
01/2024
1CarbohydratesIBA
01/2020
1Complement System Proteins (Complement)IBA
01/2020
1Immunoglobulin G (IgG)IBA
01/2020
1AntibodiesIBA
01/2020
13'-sialyllactoseIBA
01/2020
1Neutral RedIBA
01/2017
1Retinal Pigments (Pigments, Visual)IBA
01/2017
1Proteins (Proteins, Gene)FDA Link
02/2015
1EpitopesIBA
09/2014
1OligosaccharidesIBA
09/2014
1Histone Deacetylase InhibitorsIBA
09/2014
1Chemotactic FactorsIBA
04/2013
1Peptides (Polypeptides)IBA
04/2013
1ChemokinesIBA
04/2013
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
07/2012
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2012
1Matrix Metalloproteinases (MMPs)IBA
03/2012
1CalciumIBA
08/2011
1Nerve Growth Factor (NGF)IBA
11/2010
1Bleomycin (Blenoxane)FDA LinkGeneric
11/2009
1Y-Box-Binding Protein 1IBA
11/2009
1Interferon-alpha (Interferon Alfa)IBA
10/2003

Therapy/Procedure

7Therapeutics
01/2019 - 10/2003
2Oral Administration
12/2015 - 02/2011